Available online 2023-11-27, published 2023-12-15, Korean Herb. Med. Inf. 2023;11(2)

다빈도 다표적 한약 성분의 Enrichment Test 분석의 영향: TCMSP를 활용한 염증 기전 사례 연구

Analyzing the impact of high-frequency multi-target herbal medicine compounds on enrichment test: a case study on inflammation response using TCMSP

Abstract
The increasing application of network pharmacological analysis offers a novel perspective for understanding the complex interactions between herbal compounds and their multiple protein targets. However, despite the importance of these analyses, the influence of high-frequency, multi-target compounds on network pharmacological analysis is not clear. This study investigates the impact of these prevalent multi-target compounds on network pharmacological analysis. To this end, we conducted a case study focusing on the analysis of the inflammation response, utilizing enrichment analysis results derived from the TCMSP database. We confirmed that compounds such as Kaempferol and Quercetin, which are part of various herbal medicines, may be highly relevant to inflammatory responses, as indicated by the enrichment test results. Our research suggests that the network pharmacological results of traditional medicine, utilizing public data, can be influenced by compounds with high-frequency, multi-target characteristics.

Keyword: Network pharmacology, Korean medicine, TCM, database, herb, formula

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